Efficacy of Metformin use to Induce Ovulation in Women with Polycystic Ovarian Syndrome
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چکیده
Polycystic Ovarian Syndrome (PCOS), a common disorder of the endocrine system, is diagnosed based on inclusion criteria of an ovulation or oligo-ovulation, clinical signs of hyperandrogenism, and/or presence of polycystic ovaries on ultrasound. Many women with PCOS also have hyperinsulinemia, leading to over production of ovarian androgens. Due to this differential, the use of the insulin-sensitizing agent metformin has been explored to induce ovulation in women with PCOS. The use of metformin combined with the fertility drug clomiphene citrate (clomid) has shown to be more effective than the placebo in stimulating ovulation. While metformin has not yet gained the title of a first-line pharmacological agent for ovulation induction, research shows it has many benefits in PCOS treatment.
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